Cialix second heart pumping for us and at that point you're you're in a milieu that's very very reparative there's a lot of opportunity for repair and so we think that by unloading we're recapitulating some of the basic fundamental biology and physiology but the hip one experiments that we should today are the first signal that actually from a biologic perspective we may not be seeing as much ischemic burden even though the epicardial vessel is occluded and I think that's to your point and also to this point that in fact we are an anti ischemic approach as well as a anti reperfusion pathway so have you and you considered maybe looking at sort of maybe intravital microscopy to look at micro circulation to see if you actually still have a sustained flow in those regions you know that strikes me as something that could be done to actually there has been some work with that with unloading it's been done in peripheral organs so organs Cialix Male En